Perhaps the number one problem in the world is the unchecked power of mega-corporations, most commonly involved in the energy, finance, drug, armament, and insurance fields. These entities receive the benefits of being gigantic while they also receive the rights of persons. The Supreme Court has established that the money these giants pay in order to influence politicians is "free speech." The tremendous advantages thus gained allows these behemoths to maintain laws which favor their continued dominance over people and humane values.
Corporations are charged by law to seek profit, and this, along with human greed, has led to soulless profiteering, and extensive damage to humans.
Redefining the rights of corporations, taking away (or reducing) their personhood, will restore the balance of power between Big Business (AKA the ultra-rich) and the middle classes.